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KMID : 1161420170200010056
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Journal of Medicinal Food
2017 Volume.20 No. 1 p.56 ~ p.64
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The Root Extract of Gentiana macrophylla Pall. Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice
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Sheu Ming-Jen
Chiu Chun-Ching
Yang Deng-Jye
Hsu Tsai-Ching
Tzang Bor-Show
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Abstract
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The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine “Qinjiao,” have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300?mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin?eosin staining and immunoblotting. The GM root extract significantly decreased B19-NS1-exacerbated liver inflammation by suppressing the expressions of hepatic inducible nitric oxide synthase, cyclooxygenase type 2 (COX-2), interleukin (IL)-1β proteins, values of serum asparate transaminase (AST) and alanine transaminase (ALT), and lymphocyte infiltration (P?
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KEYWORD
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Gentiana macrophylla Pall. (GM), human parvovirus B19 (B19), liver inflammation, nonstructure protein NS1, systematic lupus erythomatosus (SLE)
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